Description

MOG 35-55 represents a synthetic peptide fragment corresponding to amino acids 35-55 of myelin oligodendrocyte glycoprotein, a key component of central nervous system myelin that serves as a target antigen in autoimmune demyelinating diseases. The peptide has been extensively characterized as an encephalitogenic epitope capable of inducing experimental autoimmune encephalomyelitis (EAE) in susceptible animal models, making it valuable for investigating autoimmune mechanisms and multiple sclerosis pathology. The MOG 35-55 sequence contains critical amino acid residues that are recognized by autoreactive T cells and antibodies in autoimmune demyelinating conditions. The peptide functions as an antigen that can activate myelin-specific immune responses, leading to inflammation and demyelination in research models. Research applications include investigation of autoimmune mechanisms, multiple sclerosis pathogenesis, myelin biology, and the development of therapeutic strategies for demyelinating diseases. For research use only.