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Gonadorelin is a synthetic decapeptide analogue of gonadotropin-releasing hormone (GnRH) with the amino acid sequence pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2. This research compound demonstrates gonadotropin releasing activity through GnRH receptor binding and is utilized in laboratory studies investigating reproductive endocrinology and hypothalamic-pituitary-gonadal axis function. Gonadorelin is classified as a hypothalamic releasing hormone analogue for research applications.
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Gonadorelin represents a synthetic analogue of naturally occurring gonadotropin-releasing hormone, designed to replicate the biological activity of endogenous GnRH in research applications. The compound consists of a decapeptide sequence with the structure pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2, where pGlu represents pyroglutamic acid and the C-terminus is amidated. The peptide functions through specific binding to GnRH receptors located in the anterior pituitary gland, where it activates G-protein coupled receptor signaling pathways. This activation leads to stimulation of adenylyl cyclase, increased cyclic adenosine monophosphate (cAMP) levels, and subsequent release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Research applications include studies of reproductive endocrinology, hormone regulation mechanisms, and receptor pharmacology related to the hypothalamic-pituitary-gonadal axis. For research use only.
| Weight | 4 oz |
|---|---|
| Package |
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