Description

MOTS-C represents a mitochondrial-derived peptide consisting of 16 amino acids with the sequence MRWQEMGYIFYPRKLR, encoded by the mitochondrial 12S rRNA gene and demonstrating significant metabolic regulatory properties. The compound represents one of several recently discovered mitochondrial-derived peptides that function as signaling molecules between mitochondria and other cellular compartments. MOTS-C demonstrates the ability to regulate glucose and lipid metabolism, enhance insulin sensitivity, and promote metabolic homeostasis in research models. The peptide functions through mechanisms that may involve AMPK activation, metabolic gene expression regulation, and modulation of cellular energy sensing pathways. MOTS-C has been shown to accumulate in the nucleus under metabolic stress conditions, suggesting a role in transcriptional regulation of metabolic processes. Research applications include investigation of mitochondrial biology, metabolic regulation mechanisms, aging processes, and the role of mitochondrial-derived peptides in cellular energy homeostasis. For research use only.