Description

Teriparatide represents a synthetic 34-amino acid peptide corresponding to the biologically active N-terminal fragment of human parathyroid hormone (PTH 1-34), retaining full biological activity for parathyroid hormone receptor activation and bone metabolism regulation. The compound demonstrates identical amino acid sequence to the first 34 amino acids of endogenous PTH, which contains the complete receptor binding and activation domain necessary for biological function. Teriparatide functions through specific binding to parathyroid hormone receptors (PTH1R) in bone and kidney tissues, leading to activation of adenylyl cyclase and protein kinase A signaling pathways. The peptide demonstrates anabolic effects on bone tissue through stimulation of osteoblast activity and bone formation processes. Research applications include investigation of bone metabolism mechanisms, calcium homeostasis regulation, parathyroid hormone biology, and the molecular basis of bone formation and remodeling processes. For research use only.