Description

SS-31 (also known as Elamipretide) represents a synthetic tetrapeptide with the sequence D-Arg-dimethylTyr-Lys-Phe-NH2, designed to selectively target mitochondria and provide cytoprotective effects through antioxidant mechanisms. The compound demonstrates unique properties including selective accumulation in mitochondria, stabilization of cardiolipin (a key mitochondrial membrane lipid), and protection against oxidative damage. SS-31 functions through multiple mechanisms including scavenging of reactive oxygen species, stabilization of mitochondrial membrane structure, and enhancement of mitochondrial bioenergetics. The peptide has been extensively studied for its ability to protect against mitochondrial dysfunction, improve cellular energy metabolism, and provide cytoprotection in various research models of aging, ischemia, and degenerative diseases. Research applications include investigation of mitochondrial biology, oxidative stress mechanisms, cellular aging processes, and the development of mitochondria-targeted therapeutic strategies. For research use only.