Description

Octreotide represents a synthetic octapeptide developed as a long-acting analogue of somatostatin with enhanced stability and selective receptor binding properties. The compound demonstrates preferential binding affinity for somatostatin receptor subtypes 2 and 5 (SSTR2 and SSTR5) compared to other somatostatin receptor subtypes, providing selectivity advantages for research applications. Octreotide incorporates specific structural modifications including D-amino acids and disulfide bridging that contribute to enhanced resistance to enzymatic degradation and improved pharmacokinetic properties compared to native somatostatin. The peptide functions through selective activation of SSTR2 and SSTR5, leading to inhibition of hormone secretion and modulation of cellular signaling pathways with greater selectivity than native somatostatin. Research applications include investigation of selective somatostatin receptor signaling, neuroendocrine regulation mechanisms, and the role of specific somatostatin receptor subtypes in various physiological processes. For research use only.