Description

Mechano Growth Factor represents a unique splice variant of the insulin-like growth factor-1 gene, characterized by the presence of a distinctive E-domain peptide sequence that differentiates it from other IGF-1 isoforms. The compound is naturally produced in response to mechanical stimuli, particularly in skeletal muscle tissue subjected to stretching or loading conditions. The MGF peptide contains a unique C-terminal E-domain sequence that is not present in other IGF-1 splice variants. Research has indicated that the E-domain peptide can influence cellular proliferation, particularly in satellite cells and myoblasts, through mechanisms that may involve protein kinase C (PKC) activation and nuclear translocation of transcription factors. Synthetic MGF peptides are utilized in research applications to investigate the specific contributions of the E-domain sequence to cellular responses. For research use only.