Description

Kisspeptin represents a family of neuropeptides derived from the KISS1 gene product, with kisspeptin-54, kisspeptin-14, kisspeptin-13, and kisspeptin-10 being the primary bioactive forms that regulate reproductive function through the hypothalamic-pituitary-gonadal axis. The compound demonstrates potent activity at kisspeptin receptors (GPR54/KISS1R) and plays crucial roles in the regulation of gonadotropin-releasing hormone (GnRH) secretion and reproductive physiology. Kisspeptin functions through specific binding to GPR54 receptors located on GnRH neurons in the hypothalamus, leading to stimulation of GnRH release and subsequent activation of the reproductive hormone cascade. The peptide has been identified as a key regulator of puberty onset, reproductive cyclicity, and fertility in various research models. Research applications include investigation of reproductive endocrinology, puberty mechanisms, fertility regulation, and the role of kisspeptin signaling in reproductive health and disease. For research use only.