Description

Humanin represents a 24-amino acid mitochondrial-derived peptide originally discovered for its ability to protect neurons against Alzheimer’s disease-related toxicity and subsequently characterized for broader cytoprotective properties. The compound is encoded by mitochondrial DNA and demonstrates significant neuroprotective and cytoprotective activities through multiple cellular mechanisms. Humanin functions through binding to specific receptors and modulation of cellular signaling pathways involved in apoptosis, oxidative stress response, and cellular survival. The peptide has been shown to protect against various forms of cellular stress including amyloid-beta toxicity, oxidative damage, and ischemic injury in research models. Research applications include investigation of mitochondrial biology, neuroprotection mechanisms, aging processes, and the role of mitochondrial-derived peptides in cellular survival and protection against neurodegenerative processes. For research use only.