Description

Protirelin represents a synthetic analogue of thyrotropin-releasing hormone, consisting of the tripeptide sequence pyroglutamic acid-histidine-proline amide (pGlu-His-Pro-NH2), which is identical to the naturally occurring TRH structure. The compound demonstrates high binding affinity for TRH receptors and maintains complete biological activity for thyroid-stimulating hormone release and related neuroendocrine functions. The peptide’s structure incorporates pyroglutamic acid at the N-terminus and amidation at the C-terminus, both of which are essential for biological activity and receptor binding. Protirelin functions through specific binding to TRH receptors in the anterior pituitary gland, leading to stimulation of thyroid-stimulating hormone (TSH) and prolactin release. Research applications include investigation of thyroid regulation mechanisms, hypothalamic-pituitary-thyroid axis function, and the role of TRH signaling in neuroendocrine regulation. For research use only.