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ARA-290 is a synthetic peptide derived from the structure of erythropoietin (EPO) that selectively activates the innate repair receptor (IRR). Unlike EPO, ARA-290 does not stimulate red blood cell production (erythropoiesis), thereby avoiding the associated risks such as thrombosis. Its primary action is to reduce inflammation, inhibit apoptosis (programmed cell death), and promote tissue repair. Clinical studies have shown that ARA-290 can significantly alleviate neuropathic pain, improve wound healing, and modulate the immune response, making it a promising therapeutic candidate for chronic inflammatory conditions, nerve damage, and autoimmune disorders like sarcoidosis.
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Every batch independently verified by third-party laboratories.
Ascension Peptides products are independently tested by accredited third-party laboratories. Results are batch-specific and provided for research transparency only. This product is considered research only and not approved for human use.
ARA-290 is an 11-amino acid peptide engineered to specifically target and activate the innate repair receptor (IRR), a heterocomplex of the erythropoietin receptor (EPOR) and the β-common receptor (CD131). This receptor is expressed in response to tissue injury and plays a critical role in orchestrating the body’s natural repair and anti-inflammatory processes.
The parent molecule, erythropoietin (EPO), has known tissue-protective effects but also carries the significant side effect of stimulating red blood cell production (erythropoiesis), which increases the risk of blood clots and cardiovascular events. ARA-290 was designed to isolate the tissue-protective functions of EPO from its hematopoietic effects. By selectively binding to the IRR, ARA-290 initiates a signaling cascade that is profoundly anti-inflammatory, anti-apoptotic, and pro-reparative without affecting red blood cell counts.
The mechanism of action involves the downregulation of pro-inflammatory pathways, most notably the NF-κB signaling pathway, a key regulator of the inflammatory response. By suppressing this pathway, ARA-290 reduces the production of inflammatory cytokines like TNF-α and IL-6. This targeted action has shown significant therapeutic potential in a range of conditions:
Neuropathic Pain: Clinical trials, particularly in patients with sarcoidosis-associated small fiber neuropathy, have demonstrated that ARA-290 can significantly reduce pain symptoms and promote the regeneration of small nerve fibers.
Metabolic Control: Studies in patients with type 2 diabetes have shown that ARA-290 can improve glycemic control and insulin sensitivity, likely by reducing the chronic low-grade inflammation associated with the disease.
Autoimmune and Inflammatory Disorders: Due to its potent immunomodulatory effects, ARA-290 is being investigated for use in conditions such as sarcoidosis, rheumatoid arthritis, and lupus.
Wound Healing: By promoting tissue repair and reducing local inflammation, ARA-290 has shown potential to accelerate the healing of chronic wounds.
Given its excellent safety profile and targeted, non-erythropoietic mechanism, ARA-290 represents a novel therapeutic approach for managing a wide spectrum of diseases characterized by chronic inflammation and tissue damage.
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Important information about this product
No. All products sold by Ascension Peptides are strictly for research use only (RUO). They are not approved for human or veterinary use.
Store lyophilised peptides at -20°C in a dry, dark environment. Once reconstituted, store at 4°C and use within 28 days. Avoid repeated freeze-thaw cycles.
Ascension Peptides is a research chemical company and by law we are not allowed to discuss reconstitution or dosage.
Orders placed before our 2pm CST M-Sat are typically shipped the same business day. You will receive a tracking number via email once your shipment is completed.
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