Description
T-10 represents an innovative synthetic peptide designed as a dual agonist for both glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptors, incorporating advanced peptide engineering to achieve balanced activity at both receptor systems. The compound consists of a 39-amino acid linear peptide chain with structural similarities to both GIP and GLP-1, belonging to the secretin family of gut hormones. The peptide incorporates specific amino acid modifications designed to optimize binding affinity and activation of both target receptors.
The compound features a C20 fatty diacid modification that significantly enhances stability and extends half-life through albumin binding, similar to other long-acting peptide therapeutics. This modification allows for sustained biological activity and makes T-10 suitable for research protocols requiring prolonged incretin receptor activation. The dual receptor activity profile provides unique opportunities for investigating the combined effects of GIP and GLP-1 signaling pathways in metabolic regulation.
T-10 functions through simultaneous activation of both GIP and GLP-1 receptors, leading to complementary signaling cascades that influence glucose homeostasis, insulin secretion, and metabolic regulation. The compound’s dual mechanism involves activation of adenylyl cyclase at both receptor systems, resulting in increased cyclic adenosine monophosphate (cAMP) levels and downstream effects on pancreatic beta cells, adipose tissue, and other metabolically active tissues.
Research applications of T-10 include investigation of dual incretin signaling, glucose homeostasis mechanisms, and metabolic regulation pathways. The compound’s unique dual receptor activity profile makes it valuable for studying the interactions between GIP and GLP-1 signaling systems and their combined effects on metabolic function. Research preparations typically utilize 10mg concentrations with appropriate reconstitution and storage protocols to maintain peptide stability and dual receptor activity.
For research use only.
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