Description

Gonadorelin represents a synthetic analogue of naturally occurring gonadotropin-releasing hormone, designed to replicate the biological activity of endogenous GnRH in research applications. The compound consists of a decapeptide sequence with the structure pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2, where pGlu represents pyroglutamic acid and the C-terminus is amidated. The peptide functions through specific binding to GnRH receptors located in the anterior pituitary gland, where it activates G-protein coupled receptor signaling pathways. This activation leads to stimulation of adenylyl cyclase, increased cyclic adenosine monophosphate (cAMP) levels, and subsequent release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Research applications include studies of reproductive endocrinology, hormone regulation mechanisms, and receptor pharmacology related to the hypothalamic-pituitary-gonadal axis. For research use only.